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Pear Tree Medical Associates
Internal Medicine and Pediatrics



Dr Isabelle Jeffress is a Board Certified Internist and Pediatrician. She is a 1991 graduate of Rice University, where she double majored in Biology and French. Afterward, she obtained her Doctorate of Medicine from the University of Texas Medical School at Houston in 1995. Dr Jeffress went on to complete her Internal Medicine and Pediatrics Residency in 1999. She subsequently was asked to join the faculty and worked at the University of Texas Health Sciences Center for 7 years. During that time, she served as Assistant Professor in both Internal Medicine and Pediatrics, and thus taught young doctors how to assess, diagnose and treat patients.

While at UTHSC, she was also the Medical Director of Student Health Services, where she served as the private physician to medical students and other doctors. In addition, Dr Jeffress was instrumental in providing Telemedicine medical services to patients in remote locations of South Texas, where medical care is scarce.

Dr Jeffress is a current member of local, regional, and national professional associations, including the Brazoria County Medical Society, the Texas Medical Association, and a Fellow in the American Academy of Pediatrics.

A Pearland Resident since 1995, she spends her free time with her husband Jeff and her 2 children.


Because I am a working mother of four kids, ages one to sixteen, having easy access to a family doctor is not just a “nice to have” but a necessity in life! Pear Tree Medical Associates has the best medical practice I have ever been to. Appointments are usually on time. There is nothing more frustrating than having a sick child and then having to wait for an hour for the doctor to arrive. Dr. Jeffress can treat the baby, my teenagers, as well as me and my husband. Because Dr. Jeffress sees all of us, she knows the entire family and helps with all types of issues, not just illness. Here in Pearland, we are lucky to have such a great doctor in our community. –M.B., Pearland, TX